10 Best sinus medicines of 2025

Save up to 41% off

Best Choice

1

GenCare
GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness
Main highlights

Maximum Strength Relief
10 mg Phenylephrine HCl provides strong sinus and nasal congestion relief.

Ideal for Chronic Congestion
Perfect for families or individuals with frequent allergy symptoms.

Highly Praised Value
Customers appreciate the affordability and effectiveness compared to other brands.
9.7

Exceptional

Our Rating

9.7
worth the money

9.5
dispense easily

9.3
simple to consume
How do we rank?

Powerful technology We scan thousands of products and stores, analyzing reviews to find what matters most to users like you

Careful review Our team ensures quality, value, and fit based on real user feedback

Trusted insights AI and human analysis guide your decisions, reflecting real user priorities
Real users impact

Thousands of users trust our site daily

Based on millions of stores and reviews

Shoppers influence our rankings
Analyzing top stores
Value for Money

2

Vicks
Vicks Sinex SEVERE Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Nasal Congestion due to Cold or Allergy, Sinus Pressure Relief, 265 Sprays x 2

14% Off
Main highlights

12-Hour Relief from Congestion
Provides instant, long-lasting relief from nasal congestion and sinus pressure for up to 12 hours.

Ideal for Cold and Allergy Season
Perfect for treating severe sinus congestion and pressure from colds or allergies.

Instant Effectiveness Praised by Users
Highly rated for its immediate effectiveness in clearing nasal passages.
9.5

Excellent

Our Rating

9.5
Simple to use

9.3
Moisturizing

9.1
worth the money
3

Sudafed
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

28% Off
Main highlights

Fast Powerful Relief
Provides maximum strength, non-drowsy relief for sinus congestion and pain.

Ideal for Allergy Season
Perfect for relieving nasal congestion from allergies and colds.

Customer Praised Effectiveness
Highly rated for its effective relief during allergy season.
9.4

Excellent

Our Rating

9.1
simple to consume

8.4
worth the money

8.0
Comfort
4

Tylenol
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

15% Off
Main highlights

Non-Drowsy Sinus Relief
Provides non-drowsy relief from sinus congestion, headaches, and pressure with acetaminophen and phenylephrine HCl.

Ideal for Daytime Use
Perfect for adults and children 12+ needing effective daytime sinus and headache relief.

High Quality Effectiveness
Praised for superior effectiveness compared to generic brands, ensuring reliable symptom relief.
Key specs
- features:Non-drowsy, sinus relief
- product dimensions:4.5 x 0.75 x 3 inches
- decongestant:5 mg phenylephrine HCl
- active ingredients:325 mg acetaminophen
- usage instructions:Adults and children 12+
9.1

Excellent

Our Rating

9.5
simple to consume

9.5
worth the money

9.1
Flavor
5

Tylenol
Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

28% Off
Main highlights

Non-Drowsy Symptom Relief
Provides non-drowsy relief from sinus headache, nasal congestion, and chest congestion.

Daytime Use for Adults and Teens
Ideal for adults and children 12+ needing daytime sinus relief.

Quick Decongestion Effect
Customers praise its fast-acting decongestion for stuffy head relief.
8.8

Very Good

Our Rating
See Today’s Deals & Prices
6

Mucinex
Mucinex Sinus-Max Severe Congestion Relief Caplets, 20 Count

21% Off
Main highlights

Maximum Strength Relief
Provides relief from pain, headache, nasal, sinus, and chest congestion.

Ideal for Severe Congestion
Best for adults experiencing severe sinus and nasal congestion.

Praised for Effectiveness
Customers appreciate the product's good results despite small packaging.
8.6

Very Good

Our Rating
7

Vicks
Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
Main highlights

Fast Relief for Sinus Symptoms
Experience quick relief from nasal congestion, sinus pressure, and headaches.

Ideal for Cold and Allergy Symptoms
Best for sinus issues from colds, hay fever, or allergies.

Praised for Effectiveness
Customers frequently praise its effectiveness in relieving sinus discomfort.
Key specs
- features:fast, powerful relief
- product dimensions:1.1 x 3.31 x 4.31 inches
- decongestant:non-drowsy nasal decongestant
- active ingredients:N/A
- usage instructions:N/A
8.5

Good

Our Rating
8

Advil
Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

41% Off
Main highlights

Fast Relief for Sinus and Pain
Advil Sinus Congestion and Pain offers rapid relief for sinus pressure, nasal congestion, headaches, and minor body aches.

Daytime and Nighttime Use
Ideal for adults and children 12+ for both daytime and nighttime sinus and pain relief.

Non-Drowsy Formula Praised
Customers appreciate the non-drowsy formula, allowing them to remain active and alert.
8.2

Good

Our Rating
9

Sudafed
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

29% Off
Main highlights

Powerful Sinus Relief
20-count of maximum strength tablets for day and night sinus congestion relief.

Best for All-Day Use
Ideal for relieving sinus pressure and congestion both day and night.

Fast Symptom Relief
Customers praise quick relief from sinus congestion and pressure.
Key specs
- features:Day and night relief
- product dimensions:0.64 x 4.56 x 2.88 inches
- decongestant:Phenylephrine HCl
- active ingredients:Phenylephrine HCl, Diphenhydramine HCl
- usage instructions:Adults and children 12+
8.1

Good

Our Rating

9.5
simple to consume

8.7
worth the money

8.4
pain management
10

Boiron
Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

16% Off
Main highlights

Homeopathic Sinus Relief
Targets sinus pain with a stuffy or runny nose, non-drowsy, and non-habit forming.

Convenient for All Ages
Sweet pellets melt under the tongue, suitable for ages 6 and up.

Effective Symptom Relief
Praised for effectively stopping constant runny nose and congestion.
8.0

Good

Our Rating

9.3
simple to consume

8.2
Flavor

8.0
worth the money

10 Best sinus medicines of 2025

1

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

9.7

9.5

9.3

How do we rank?

How do we rank?

Analyzing top stores

2

Vicks Sinex SEVERE Allergy & Sinus Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Nasal Congestion due to Cold or Allergy, Sinus Pressure Relief, 265 Sprays x 2

9.5

9.3

9.1

3

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

9.1

8.4

8.0

4

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

9.5

9.5

9.1

5

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

6

Mucinex Sinus-Max Severe Congestion Relief Caplets, 20 Count

7

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

8

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

9

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

9.5

8.7

8.4

10

Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

9.3

8.2

8.0

Sign up and get exclusive special deals